There is currently no scientific consensus in either the U.S. or the EU linking glyphosate exposure to gluten sensitivity or celiac disease. However, in June 2025, glyphosate’s toxicity was confirmed in a comprehensive carcinogenicity study led by the Cesare Maltoni Cancer Research Center of the Ramazzini Institute, in collaboration with scientists from Europe and the U.S.
Given these differences, many consumers — and chefs like Osso — prefer ingredients grown with fewer synthetic inputs.
PROCESSING & FERMENTATION: THE MISSING LINK?
Even when the same grains are used, the preparation process matters. Traditional Italian bread and pizza doughs often undergo long fermentation — anywhere from 24–72 hours — which allows natural enzymes and yeasts to break down gluten and reduce fermentable carbohydrates known to cause digestive distress.
“The fermentation process has a lot to do with making pizza, focaccia, pastries, and some breads easily digestible,” Osso explains. “That’s the goal — especially with Napoletana-style pizza.”
In contrast, many commercial breads in the U.S. rely on rapid-rise methods, dough conditioners, or shorter fermentation windows that leave more complex gluten structures intact.
SO WHAT’S REALLY GOING ON?
Many factors — wheat variety, farming practices, fermentation, and even stress levels — may explain why some people feel better eating gluten abroad. But there doesn’t appear to be a single cause for everyone.
When crafting his own menus, Osso considers these factors when selecting the flour. “I specifically use an imported brand from Italy called Caputo,” he said. “They are the industry standard when it comes to Napoletana pizza… consistent, clean, and perfect for any application I need.”
THE BOTTOM LINE
The rise in gluten sensitivity is real, and the better experience many travelers have with gluten-based foods in Europe is equally genuine. Choosing higher- quality grains, minimally processed flours, and doughs with longer fermentation periods may offer similar benefits at home.